Professor of Urology; O’Brien Center Director; UWMF-Professor of Urologic Research; Director of Research
Perturbation of the Hormonal Milieu Produces Lower Urinary Tract Dysfunction
We propose that sex steroid hormones promote fibrosis of the prostate, which in turn leads to the development of lower urinary tract dysfunction. Furthermore, we are elucidating estrogen hormone action by performing mechanistic studies that underpin molecular pathways involved in BPH/fibrosis. The expectation of these studies is to identify how fibrosis is associated with BPH/LUTS and develop therapeutic targets towards currently unknown pathways involved in BPH and hence prevent or treat BPH/LUTS.
Alton J. Brann Distinguished Professor in Science and Mathematics; Professor of Biological Sciences; Director, Center for Personalized Cancer Therapy
CXCL12/CXCR4 Axis Activation in Lower Urinary Tract Fibrosis and Dysfunction
We hypothesize that activation of the CXCL12/CXCR4 axis in the aging prostate promotes myofibroblast phenoconversion and tissue fibrosis through non-canonical mechanisms coupled to EGFR transactivation and MEK/ERK signaling. We will test this hypothesis using in vitro and in vivo models and per-urethral tissues from men with or without obstructive lower urinary tract dysfunction.
Professor of Pharmaceutical Sciences; Associate Dean of Research; Vice Chair of Pharmaceutical Sciences
Phone (608) 890-2150
Research in the Marker laboratory is focused on understanding the biology of the prostate gland at the molecular level with a particular interest in the role of intercellular communication between epithelial and mesenchymal/stromal cells during prostatic branching morphogenesis and during the progression of prostate cancer.
Associate Professor of Comparative Biosciences
Roles of Beta-catenin in Urinary Dysfunction
We propose that changing hormone levels in aging men and/or reactivation of a developmental growth-regulatory pathway mediated by beta-catenin are underlying causes of benign prostatic hyperplasia. The hypothesis will be tested using a genetic approach in mice and by analyzing human prostate specimens.
O’Brien Center Co-Director; Professor of Surgical Sciences; Associate Dean of Research School of Veterinary Medicine
Rodent Urinary Function Testing (RUFT) Core
Our facility performs critical assessment of lower urinary function testing in mice. The RUFT is actively engaged in expanding techniques and technology available for assessment of lower urinary tract function in mice. The Biomedical Core facilitates access to specialized histological services. Services of the Biomedical Core are also available to external investigators.