Jill Macoska, PhD
Alton J. Brann Distinguished Professor in Science and Mathematics; Professor of Biological Sciences; Director, Center for Personalized Cancer Therapy
CXCL12/CXCR4 Axis Activation in Lower Urinary Tract Fibrosis and Dysfunction
We hypothesize that activation of the CXCL12/CXCR4 axis in the aging prostate promotes myofibroblast phenoconversion and tissue fibrosis through non-canonical mechanisms coupled to EGFR transactivation and MEK/ERK signaling. We will test this hypothesis using in vitro and in vivo models and per-urethral tissues from men with or without obstructive lower urinary tract dysfunction.