William Ricke, PhD
Professor of Urology; O’Brien Center Director; UWMF-Professor of Urologic Research; Director of Research
Perturbation of the Hormonal Milieu Produces Lower Urinary Tract Dysfunction
We propose that sex steroid hormones promote fibrosis of the prostate, which in turn leads to the development of lower urinary tract dysfunction. Furthermore, we are elucidating estrogen hormone action by performing mechanistic studies that underpin molecular pathways involved in BPH/fibrosis. The expectation of these studies is to identify how fibrosis is associated with BPH/LUTS and develop therapeutic targets towards currently unknown pathways involved in BPH and hence prevent or treat BPH/LUTS.