Research undertaken at the UW-Madison George M. O’Brien Center for Benign Urology Research is dedicated to improving urologic health in aging men. The center is a multi-site research cooperative between the University of Wisconsin-Madison, University of Massachusetts-Boston, University of Texas-Southwestern, and the National Institutes of Health (NIH).


The O’Brien Centers were established by the NIDDK in 1987 as P50 programs and worked independently. They were converted to the U54 mechanism in 2012 to encourage collaboration between funded centers and sharing with the larger research community with the following mission:

  • Support the next generation of urologic researchers by providing meaningful education, support, and mentoring
  • Cultivate new research tools and ideas by expanding the collaborative network within and outside of the traditional urologic research field
  • Enhance knowledge of mechanisms associated with normal development, function, and disease pathology related to the urinary tract, kidney, and prostate
  • Translate knowledge and tools generated from our collaborations to the clinical setting to reduce the burden of benign urologic illness by developing and testing therapies to better treat, manage, and prevent these diseases


The goals of the O’Brien Center are to:

  • Identify factors that cause urinary dysfunction in aging men
  • Build consensus around research approaches to model urinary dysfunction in rodents
  • Provide opportunities for established investigators to transition into the field of benign urology
  • Secure the future of urologic research by promoting development of the next generation of urologic researchers
  • Disseminate urologic research knowledge through seminars, workshops and symposia

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